MAINTENANCE

The management of marketing authorisation documentation and regulatory compliance are becoming an increasingly important part of regulatory activities. We provide advice and support with the implementation of all measures associated with general concepts, including the assumption of all work, or certain aspects of them in case of capacity issues.

  • Classification, processing and submission of national and European variations
  • Annual Reports
  • Processing, compilation and submission of line extensions
  • Processing, compilation and submission of national and European renewal applications
  • Submission of PSURs (PSUR repository, eSubmission Gateway)
  • Sunset clause notifications (SSC notifications)
  • Review of the validity of product information texts
  • Review of conformity with manufacturing documents (regulatory compliance)
  • Development of strategies for responding to deficiency letters

VARIATIONS

Our service for processing variations includes:

  • Assessment and implementation of change control procedures
  • Classification of variations (IA, IB, II, line extension, Article 63(1))
  • Implementation of requests from the authorities
  • Compliance with conditions and commitments
  • Preparation of application forms
  • Organising fee payment
  • Processing of CMC documents, revision of marketing authorisation dossiers
  • Expert reports (Modules 2.3 – 2.7)
  • Submission of documents
  • Processing deficiency letters
  • Communication with authorities
  • Monitoring deadlines

RENEWALS

Our services for processing renewal procedures include:

  • Implementation of requests from the authorities
  • Preparation of application forms
  • Advice for the preparation of quality statements
  • Expert reports (Addendum Modules 2.3 and 2.5)
  • Compliance with conditions and commitments
  • Submission of the documents
  • Processing deficiency letters
  • Organising fee payment
  • Communication with authorities
  • Monitoring deadlines